The protein C inhibitory system
Kase, F.; Spurling, N.W.; Pospísil, J.
Folia Haematologica 114(6): 737-750
1987
ISSN/ISBN: 0323-4347 PMID: 2453403 Document Number: 288489
The chemical and physical characteristics of the individual components of the protein-C inhibiting system, protein C, thrombomodulin, protein S and the inhibitor of the activated protein C are summarized in a survey, with their mutual relations and their physiological impact on the course of the coagulating and fibrinolytic systems being represented. Finally, the clinical implications of a hereditary and acquired protein C deficiency, of a diminished protein S level and a lowered inhibitor of the activated protein C are discussed. The complications caused by a rapid decline of protein C values after administration of coumarin derivates are referred too.