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Mutagenicity studies on thymomodulin

Cantelli-Forti, G.; Hrelia, P.; Scotti, M.; Scornavacche, V.; Prada, M.

Arzneimittel-Forschung 37(11): 1269-1273

1987

ISSN/ISBN: 0004-4172
PMID: 3326604
Document Number: 286645
Thymomodulin (Leucotrofina), an orally administrable thymic derivative endowed with interesting immunomodulating and myelomodulating properties, was tested for mutagenicity by means of the following in vitro and in vivo tests: mutagenesis on Salmonella typhimurium with and without metabolic activation system (S-9), gene conversion on Saccharomyces cerevisiae D 7 with and without metabolic activation, urinary assay in the mouse with and without metabolic activation, urinary assay in the mouse with S. cerevisiae D 7, host mediated assay in the mouse with S. cerevisiae an DNA repair test with and without metabolic activation. On the basis of the results obtained thymomodulin proved to be free of mutagenic activity.

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