Mutagenicity of vinyl chloride. External chromosome studies on persons with and without VC illness, and on VC exposed animals
Fleig, I.; Thiess, A.M.
Journal of Occupational Medicine. Official Publication of the Industrial Medical Association 20(8): 557-561
1978
ISSN/ISBN: 0096-1736 PMID: 567683 Document Number: 4362
Chromosome analysis was undertaken on lymphocyte cultures taken from (1) six workers with estimated exposure to VC and four workers with monitored exposure to VC (employed in the BASF); (2) 20 workers showing symptoms of VC illness with unknown exposure and one angiosarcoma case, due to VC exposure (not employed in the BASF); and, (3) on bone marrow cells of Chinese hamsters after inhalation of 2,500 ppm or 5,000 ppm, or after intraperitoneal injections of 300 mg/kg or 600 mg/kg. The proband groups showing symptoms of VC illness, the only living angiosarcoma case, and the animal test show a significant increase in the rate of aberrations in comparison to the control group.
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