Chromosome investigations of persons exposed to dimethylcarbamoyl chloride and diethylcarbamoyl chloride
Fleig, I.; Thiess, A.M.
Journal of Occupational Medicine. Official Publication of the Industrial Medical Association 20(11): 745-746
1978
ISSN/ISBN: 0096-1736 PMID: 712441 Document Number: 125687
Suspected carcinogenic or mutagenic effects of dimethylcarbamoyl chloride and diethylcarbamoyl chloride are investigated in 10 human subjects exposed to these substances for 4-10 yr. Karyotypic analysis of lymphocytic cultures incubated with phytohemagglutinin reveals statistically insignificant numbers of chromosome aberrations when compared to unexposed control groups. Endomitosis consisting of tetraploid cells with diplochromosomes are reported in metaphases (1-2%) of lymphocyte and fibroblast cultures.