Biochemical characteristics of the anti-ischemic action of the new structural analog of gamma-butyrobetaine 3- (2,2,2,-trimethylhydrazine) propionate
Simkhovich, B.Z.; Meĭrena, D.V.; Khagi, K.B.; Kalvin'sh, I.I.; Lukevits, E.I.
Farmakologiia i Toksikologiia 50(2): 100-104
1987
ISSN/ISBN: 0014-8318 PMID: 3582624 Document Number: 286464
A structural analogue of gamma-butyrobetaine 3-(2,2,2-trimethylhydrazine)propionate (THP) administered orally in doses of 50 and 150 mg/kg for 10 days prevented isoproterenol-induced increase of the activity of the hepatic isoform of lactate dehydrogenase in the rat blood serum and in a dose of 150 mg/kg prevented an increase of creatine phosphokinase activity. Against a background of the course administration of THP isoproterenol failed to cause the accumulation of acyl-insoluble acylcarnitine in the myocardium. In this case a dose-dependent decrease of free carnitine concentration and accumulation of fatty acids in the myocardium were noted. The cardioprotective effect of THP manifested itself in prevention of a decrease of ATP and ADP concentrations, accumulation of AMP and a reduction of energy charge under the influence of isoproterenol. The ability of THP to decrease the intracellular concentration of free carnitine and to depress as a result carnitine-dependent oxidation of free fatty acids may underlie the anti-ischemic effect of THP.