Structural properties and lipid-binding characteristics of plasma fibrinogen and gamma-globulins in vitamin D-deficient rickets
Apukhovskaia, L.I.; Antonenko, L.V.; Kholodova, I.D.; Voziian, P.A.; Solodova, E.V.
Voprosy Meditsinskoi Khimii 34(6): 49-53
1988
ISSN/ISBN: 0042-8809 PMID: 2467438 Document Number: 308243
Structure properties and lipid-binding ability of fibrinogen and gamma-globulins were studied in blood plasma of children with rickets. Content of cholesterol and its esters, developing complexes with fibrinogen, was found to increase simultaneously with a decrease in the phospholipids, containing in the protein fraction, under conditions of the disease. Surface charge of the proteins studied, especially of fibrinogen, was altered, thus demonstrating the distinct impairments of their structure and functions. Lipid environment appears to be of importance in functional activity of these proteins.