On the NADPH dependent reaction of cytoplasmic sn-glycerol-3-phosphate dehydrogenase
Jancsik, V.; Keleti, T.
Biochemistry International 13(5): 819-826
1986
ISSN/ISBN: 0158-5231 PMID: 3814159 Document Number: 285707
Cytoplasmic sn-glycerol-3-phosphate dehydrogenase (EC. 1.1.1.8.) can reduce dihydroxy acetone phosphate with NADPH as coenzyme under in vitro conditions, in solutions of low ionic strengths, at pH values lower than 7. The reaction is inhibited by phosphoenolpyruvate, NAD, ATP, ADP and Pi. In the cell this reaction can occur apparently only in case of specific metabolic conditions, i.e. when the local pH is low and the enzyme is protected from the inhibition by the above listed metabolites.
Document emailed within 1 workday
Related Documents
Glushankov, E.P.; Epifanova, I.E.; Kolotilova, A.I. 1976: The pentose phosphate pathway and NADP-dependent glycerol-3-phosphate dehydrogenase activity in some tissues of albino rat Biokhimiia 41(10): 1788-1790Rittmann, L.S.; Johnston, S.M.; Fondy, T.P. 1977: Forms of cytosolic nicotinamide adenine dinucleotide-linked glycerol-3-phosphate dehydrogenase in normal and neoplastic mouse tissues Cancer Research 37(8 Part 1): 2673-2679
Rohde, K.; Blanck, J.; Ruckpaul, K. 1983: Kinetics of elementary steps in the cytochrome P-450 reaction sequence. VI. Model treatment of the NADPH-dependent first electron transfer reaction between cytochrome P-450 reductase and cytochrome P-450 LM2 in solution Biomedica Biochimica Acta 42(6): 651-662
Kaliman, P.A.; Petrenko, V.V.; Manandkhar, S.P.; Bomko, T.V. 1991: Activity of cytoplasmic NADP-dependent dehydrogenase in rat liver during induction of cytochrome P-450 by phenobarbital Ukrainskii Biokhimicheskii Zhurnal 63(2): 52-58
Tabata, M.; Kido, T.; Totani, M.; Murachi, T. 1985: Direct spectrophotometry of magnesium in serum after reaction with hexokinase and glucose-6-phosphate dehydrogenase Clinical Chemistry 31(5): 703-705
Gaĭnutdinov, M.K.; Konov, V.V.; Ishmukhamedov, R.N.; Zakharova, T.N.; Khalilova, M.A.; Mamatova, Z.A.; Asrarov, M.I.; Mirmakhmudova, S.I. 1990: Regulation of thyroid hormones of the interaction of mitochondria with low-molecular weight cytoplasmic mediators, induced by phosphate- dependent transport of K+ and H+ ions through the mitochondrial inner membrane Biokhimiia 55(12): 2239-2246
Tokarev, Y.N.; Chernyak, N.B.; Batishchev, A.I.; Lamzina, N.V.; Alexeyev, G.A. 1979: Study of the electrophoretic and kinetic properties of erythrocyte glucose-6-phosphate dehydrogenase in hereditary enzyme deficiencies. Description of a new variant of glucose-6-phosphate dehydrogenase: the Gd Kremenchug Nouvelle Revue Francaise d'Hematologie 20(4): 557-564
Weidemann, G.; Anselstetter, V. 1977: Multiple forms of NADPH-dependent glutathione reductase in serum. Studies on the NADPH-dependent glutathione-reductase in serum Ii Journal of Clinical Chemistry and Clinical Biochemistry 15(8): 411-417
Bel'chenko, D.I.; Khanina, N.I.; Kapustin, A.V. 1983: Glucose-6-phosphate dehydrogenase and lactate dehydrogenase activities and lactate dehydrogenase isoenzyme spectrum in human myocardium after sudden death caused by acute alcohol intoxication and ischemic heart disease Voprosy Meditsinskoi Khimii 29(3): 80-82
Khlebarova, M.; Dinkov, L.; Tsoncheva, A. 1971: Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activity in animals with experimental ketosis Eksperimentalna Meditsina i Morfologiia 10(3): 157-163
Drel', K.A.; Shelest, I.P. 1976: Lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity in the erythrocytes in diabetes mellitus Voprosy Meditsinskoi Khimii 22(4): 469-472
Stabrovskaia, V.I.; Braun, A.D. 1978: Changes in lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity in the course of muscle alteration Tsitologiia 20(9): 1040-1045
Tsapok, P.I.; Meshchishen, I.F. 1978: Adenosine triphosphatase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity of pancreas of thyroidectomized rats Ukrainskii Biokhimicheskii Zhurnal 50(3): 322-324
Kudriavtseva, G.V.; Denisova, I.I. 1980: Determination of half-life time for the key enzymes of the pentose phosphate pathway--glucose-6-phosphate dehydrogenase and transketolase Biokhimiia 45(1): 118-123
Goldenberg, D.M.; Bhan, R.D.; Pavia, R.A. 1971: In vivo human-hamster somatic cell fusion indicated by glucose 6-phosphate dehydrogenase and lactate dehydrogenase profiles Cancer Research 31(8): 1148-1152
Fomina, M.P. 1973: Activity of hexokinase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in intact and sympathectomized rat testes exposed to hormones Voprosy Meditsinskoi Khimii 19(6): 582-586
Bergstedt, S.E.; Bergstedt, J.L.; Fujimoto, K.; Mansbach, C.; Kritchevsky, D.; Tso, P. 1991: Effects of glycerol tripalmitate and glycerol trioleate on intestinal absorption of glycerol tristearate American Journal of Physiology 261(2 Pt 1): G239-G247
Doty, R.T.; Clark, E.A. 1996: Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation Journal of Immunology 157(8): 3270-3279
Bikbulatov, R.M.; Egiazarian, L.A.; Vanag, K.A. 1973: Succinate dehydrogenase, NAD-H2- and NADPH-H2-diaphorase activity in a herpetic infection of a cell culture Voprosy Virusologii 18(6): 686-689
Sanyal, S.; Patra, P.B.; Biswas, N.M. 1978: Histochemical studies on the long term prostaglandin treatment on adrenal delta5-3beta-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase activities in rats pretreated with estradiol dipropionate Anatomischer Anzeiger 144(3): 214-219