Histochemical studies on the long term prostaglandin treatment on adrenal delta5-3beta-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase activities in rats pretreated with estradiol dipropionate
Sanyal, S.; Patra, P.B.; Biswas, N.M.
Anatomischer Anzeiger 144(3): 214-219
1978
ISSN/ISBN: 0003-2786 PMID: 742713 Document Number: 137493
Long term prostaglandin E2 [PGE2] treatment stimulates adrenal weight and steroid output. Indirect studies with histochemical localization of steroidogenic enzymes and hepatocyte glycogen content revealed that in state of adrenal suppression, PGE2 fails to elicit a positive change in steroid output from adrenal cortex, although it apparently increases the enzymatic staining reactions. The action of prostaglandin on adrenal steroidogenesis is probably a pharmacologic rather than physiologic response.