Haematological changes induced in the mouse by the isomers of dimethylmyleran and myleran
Hemsworth, B.N.
Anticancer Research 6(5): 1133-1136
1986
ISSN/ISBN: 0250-7005 PMID: 3800321 Document Number: 284399
Both meso and racemic forms of dimethylmyleran are more powerful inhibitors of haematopoiesis than myleran. All produced a characteristic pattern of haematological response in which neutropenia predominated. Myleran exerted its severest depression of neutrophils immediately, whereas the isomers produced maximal damage a week later. Neutropenia induced by the .+-. isomer was persistent for 3 weeks.