Use of vecuronium bromide administered at a constant rate during renal transplantation
Richard, J.P.; Conil, J.M.; Antonini, A.; Bareille, P.
Cahiers d'Anesthesiologie 34(2): 125-126
1986
ISSN/ISBN: 0007-9685 PMID: 2872948 Document Number: 284270
The authors describe a technique of vecuronium bromide perfusion at constant flow used to obtain curarisation during 50 renal transplantations. The muscular effects of the drug were monitored through an electromyographical recorder, so as to adjust the perfusion rate. The dose of vecuronium bromide was 47.7 +/- 0.74 micrograms X kg-1 X h-1 (mean +/- SEM), this being lower than the dose recommended by D'Hollander (60 micrograms X kg-1 X h-1) for patients with normal renal function. Furthermore, no recurarisation was observed. Therefore, vecuronium can be considered as a satisfactory muscle relaxant in patients with renal failure, but neuromuscular monitoring appears to be a most important safety factor.