Angioedema and paradoxical bronchoconstriction secondary to ipratropium bromide/salbutamol administered by metered dose inhaler in patients with soy allergy
Morfin-Maciel, B.M.ía.; Castillo-Morfin, B.M.ía.
Revista Alergia Mexico 58(4): 219-223
2011
ISSN/ISBN: 0002-5151 PMID: 24007833 Document Number: 10960
There are some reports on the association between the use of ipratropium bromide/salbutamol and paradoxical bronchoconstriction and urticaria in patients with soy allergy. We describe four patients who displayed angioedema and paradoxical bronchoconstriction secondary to ipratropium bromide/salbutamol administered by metereddose-inhaler (MDI). In all of them soy allergy was demonstrated. Four patients, two children and two adults, exhibited paradoxical bronchoconstriction and angioedema secondary to ipratropium bromide/salbutamol administered by MDI. In all of them, soy allergy was substantiated by skin prick test and IgG/IgE RAST. The symptoms quickly disappeared with antihistaminics and nebulized salbutamol. In the cases where paradoxical bronchoconstriction and angioedema associated with the use of ipratropium bromide/salbutamol in MDI an immediate hypersentivity reaction to soy was confirmed, which is used as an additive in the MDI, through allergen-specific IgE determination and skin tests.
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