Hepatic diffusion of ceftriaxone
Lucht, F.; Tigaud, S.; Brun, M.; Mahul, P.; Peyramond, D.; Bertrand, J.L.
Pathologie-Biologie 34(5 Part 2): 559-560
1986
ISSN/ISBN: 0369-8114 PMID: 3534742 Document Number: 283056
We studied the intrahepatic diffusion of ceftriaxone, a new third generation, very potent cephalosporin with a long serum half-life. Sixteen patients had percutaneous liver biopsy for suspected liver disease or protracted fever of unknown origin. Serum samples and liver biopsy specimens were taken simultaneously. Serial determinations of ceftriaxone concentrations showed that the hepatic half-life was significantly shorter than the serum half-life. We suggest that ceftriaxone be used in higher or more closely spaced doses for the treatment of liver infections.