Comparison of the diffusion of ceftriaxone in digestive surgery after a single administration at doses of one and two grams
Lokiec, F.; Boudinet, A.; Petot, P.
Pathologie-Biologie 35(5): 448-450
1987
ISSN/ISBN: 0369-8114 PMID: 3302845 Document Number: 288337
Twenty patients undergoing gastrointestinal surgery were randomly allocated to receive either 1 or 2 g of ceftriaxone, a long half-life third generation cephalosporin, as a single dose intravenous prophylaxis on induction of anaesthesia. Plasma and tissue samples were taken 2 hours and analysed with an HPLC procedure. The results of plasma and tissue concentrations of ceftriaxone showed that 1 g dosage was enough for preventing the occurrence of postoperative sepsis. No adverse reaction or side-effects were recorded.