Ceftriaxone treatment failure of meningitis due to penicillin and ceftriaxone resistant streptococcus pneumonia
Ghazal, S.S.; Chowdhury, D.; Tufenkeji, H.; Al-Howasi, M.; Ali, S.M.; Aminur, M.
Saudi Medical Journal 19(4): 510-513
1998
ISSN/ISBN: 0379-5284 PMID: 27704130 Document Number: 493108
Third generation cephalosporins (cefotaxime and ceftriaxone in particular) are widely used for empirical treatment of bacterial meningitis. However reports from different parts of the world documented occurrence of meningitis due to Streptococcus pneumonia resistant to third generation cephalosporins with Minimum Inhibitory Concentration equal to or greater than 2 microgram/ml. We are reporting a case of meningitis in the Middle East, caused by Streptococcus pneumonia with intermediate resistance to ceftriaxone and penicillin, where combined and prolonged course of ceftriaxone (14 days) with penicillin (10 days) failed to clear the cerebrospinal fluid.