Inhibitory effect of various hydrazine derivatives on the activity of L-phenylalanine ammonia-lyase from Rhodotorula glutinis
Munier, R.L.; Bompeix, G.; Saindrenan, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 180(3): 302-308
1986
ISSN/ISBN: 0037-9026 PMID: 2946374 Document Number: 282590
The inhibitory activities of hydrazinoacetic acid (HAA), 2-hydrazinoethanol (HE) and ethyl hydrazino-acetate (EHA) are characterized and compared with those of L-or D-alpha-hydrazino-beta-phenylpropionic acid (L-or D-HPPA), 2-phenylethylhydrazine (PEH), hydrazine (H), alpha, beta-dihydrocinnamic acid (DHCA) and D-phenylalanine (D-Phe). Inhibitors can be arranged in order of increasing activity: HE less than EHA less than H less than D-Phe less than HAA less than D-HPPA less than DHCA less than PEH less than L-HPPA. Relations between activity and structure of inhibitors are discussed.