Effect of dioxadet on tumors transplanted to the brain
Stukov, A.N.; Korsakov, M.V.; Khrapova, T.N.; Kil'maeva, N.E.; Kraĭz, B.O.
Voprosy Onkologii 32(10): 64-67
1986
ISSN/ISBN: 0507-3758 PMID: 3776129 Document Number: 282285
A newly-developed antitumor drug Dioxadet is capable of passing the blood-brain barrier. The specific activity of rat brain tissue ranged 8-55% of that of blood at different periods after intraperitoneal injection of 14C-labelled Dioxadet. Dioxadet treatment of mice and rats bearing intracranially-transplanted L1210 leukemia and glioma 35 was followed by a 38-48 and 29% increase in survival, respectively.
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