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An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice

Andrei, G.M.; Lampuri, J.S.; Coto, C.E.; de Torres, R.A.

Experientia 42(7): 843-845

1986

ISSN/ISBN: 0014-4754
PMID: 3015669
Document Number: 282048
Treatment of neonatal mice with an antiviral factor (AVF), obtained from the leaves of Melia azederach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures.

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