Top Abstract Purchase Related
Home
>
Node
>
Subnode

Endotoxin-induced changes in nitrogen metabolism

Kilpatrick-Smith, L.; Yoder, M.C.; Polin, R.A.; Douglas, S.D.; Erecińska, M.

Research Communications in Chemical Pathology and Pharmacology 53(3): 381-398

1986

ISSN/ISBN: 0034-5164
PMID: 3534981
Document Number: 281440
Intraperitoneal administration of a sublethal dose of E. coli endotoxin to fasted rats produced within 12 hrs a rise in plasma ammonia, urea, glutamine, glutamate and aspartate as compared to controls. At this time, hepatic ureagenesis also increased as did the levels of glutamate, glutamine, aspartate, alanine and asparagine. However, liver glucose and ketone levels were unchanged. Hepatic [ATP]/[ADP] ratios declined in endotoxin-treated animals and there was an oxidation of mitochondrial pyridine nucleotides and a reduction of cytosolic pyridine nucleotides. The results suggest that impairment of nitrogen metabolism is an early effect of endotoxemia.

Document emailed within 1 workday
Secure & encrypted payments

Lang, C.H.; Cooney, R.; Vary, T.C. 1996: Central interleukin-1 partially mediates endotoxin-induced changes in glucose metabolism American Journal of Physiology 271(2 Pt 1): E309-E316
Utley, P.R.; Bradley, N.W.; Boling, J.A. 1970: Effect of water restriction on nitrogen metabolism in bovine fed two levels of nitrogen Journal of Nutrition 100(5): 551-556
Sarafov, D.; Mitkov, D.; Dzhambazova, S. 1994: Effect of a balanced amino acid-based diet on the nitrogen metabolism in carbon tetrachloride-induced liver injury Folia Medica 36(1): 13-20
Przybylska, T.; Niewiedziol, B. 1988: Selected aspects of amino acid-protein metabolism in juvenile onset insulin-dependent diabetes mellitus. I. Serum alpha-amino nitrogen level and diurnal urinary excretion of alpha-amino nitrogen and total nitrogen Pediatria Polska 63(1): 20-27
Fletcher, J.R.; Ramwell, P.W. 1980: The effects of prostacyclin (PGI2) on endotoxin shock and endotoxin-induced platelet aggregation in dogs Circulatory Shock 7(3): 299-308
Moore, J.N.; Cook, J.A.; Morris, D.D.; Halushka, P.V.; Wise, W.C. 1990: Endotoxin-induced procoagulant activity, eicosanoid synthesis, and tumor necrosis factor production by rat peritoneal macrophages: effect of endotoxin tolerance and glucan Circulatory Shock 31(3): 281-295
Kuttner, R.E.; Ebata, T.; Schumer, W. 1984: The mediated effect of endotoxin and lead upon hepatic metabolism Surgery Gynecology and Obstetrics 159(4): 319-324
Orskov, E.R.; Grubb, D.A. 1979: The minimal nitrogen metabolism of lambs Proceedings of the Nutrition Society 38(2): 24a
Abernathy, C.O.; Zimmerman, H.J.; Utili, R. 1980: Effects of endotoxin-tolerance on in vivo drug metabolism in mice Research Communications in Chemical Pathology and Pharmacology 29(1): 193-196
Pentiuk, A.A.; Petrovskaia, A.P.; Dmitriev, D.V.; Dmitrieva, E.I.; Iavorskiĭ, A.N.; Durnev, A.D. 2001: Various mechanisms of the depriming effect of bacterial endotoxin on drug metabolism Eksperimental'naia i Klinicheskaia Farmakologiia 64(5): 56-59
Schauer, F. 1988: Oxygen regulation of nitrogen metabolism in microorganisms Zentralblatt für Mikrobiologie 143(3): 195-206
Aronova, B.N. 1981: Nitrogen metabolism in healthy infants up to 1 year old Voprosy Pitaniia 3: 17-19
Penson, J.; Budny-Liberek, A. 1972: Nitrogen metabolism in acute renal insufficiency Materia Medica Polona. Polish Journal of Medicine and Pharmacy 4(4): 190-197
Buttery, P.J.; Boorman, K.N.; Barratt, E. 1973: The energy cost of nitrogen metabolism in chicks Proceedings of the Nutrition Society 32(2): 80A-81A
Luft, V.M.; Tkachenko, E.I.; D'iakonov, M.M.; Sokolov, V.A.; Stoliarova, N.A.; Bakulin, I.G.; Ruleva, S.V.; Vlasova, S.A. 1992: Status of nitrogen metabolism in reducing-diet therapy Voprosy Pitaniia 1: 17-21
Zak, R. 1985: Nitrogen metabolism and mechanisms of protein synthesis and degradation Circulation 72(5 Part 2): Iv13-Iv17
Balog, P.; Dvorzhak, E. 1972: Effect of drugs on nitrogen metabolism in diabetic patients Problemy Endokrinologii 18(4): 34-37
Bhagat, B.; Beaumont, M.; Rawson, L.; Sulakhe, P.V.; Dhalla, N.S. 1974: Calcium metabolism and contractility of isolated cardiac muscle from endotoxin-treated guinea pig Recent Advances in Studies on Cardiac Structure and Metabolism 4: 305-328
Bagby, G.J.; Lang, C.H.; Giaimo, M.E.; Spitzer, J.J. 1986: Increased glucose metabolism by epitrochlearis muscle removed from endotoxin-treated rats Circulatory Shock 20(3): 171-179
Vysotskiĭ, V.G.; Agureev, A.N.; Brantova, S.S. 1975: Excretion of end products of nitrogen metabolism in the urine in protein deficiency in man Voprosy Pitaniia 5: 27-35