Effect of trimethaphan-induced hypotension on pituitary-adrenocortical function
Murakawa, T.; Yamashita, M.; Wakayama, S.; Kudo, M.; Matsuki, A.; Oyama, T.
Masui. Japanese Journal of Anesthesiology 35(3): 407-410
1986
ISSN/ISBN: 0021-4892 PMID: 3012136 Document Number: 281377
Plasma levels of cortisol, ACTH and aldosterone were measured in 6 patients during trimethaphan-induced hypotension under halothane-nitrous oxide-oxygen anesthesia in neurosurgical procedures. Trimethaphan was infused at a rate of 10 to 30 .mu.g/kg/min so as to maintain the systolic blood pressure around 80 to 100 mm Hg. Plasma levels of cortisol, ACTH and aldosterone increased gradually during surgery, reaching the highest value after the emergence from anesthesia. No significant changes in plasma levels of cortisol, ACTH and aldosterone were detected during trimethaphan infusion compared with the values before the infusion. The authors' findings suggest that the trimethaphan-induced hypotension during halothane-nitrous oxide-oxygen anesthesia for brain surgery exerts no significant influence on pituitary adrenocortical function.