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Synthesis, characterization, and quantitation of para-hydroxymethadone, a metabolite of methadone in the rat

Gerardy, B.M.; Kapusta, D.; Dumont, P.; Poupaert, J.H.

Drug Metabolism and Disposition the Biological Fate of Chemicals 14(4): 477-481

1986

ISSN/ISBN: 0090-9556
PMID: 2873996
Document Number: 281085
To demonstrate a p-hydroxylation process in the metabolism of methadone, we have synthesized para-hydroxymethadone and characterized it by spectroscopy (IR, 13C-NMR, mass spectrometry) and chromatography (thin layer chromatography, gas-liquid chromatography, and HPLC). para-Hydroxymethadone was isolated by HPLC from the urine of rats treated with (R,S)-methadone. para-Hydroxymethadone in the urine and in the bile represents 1.82 and 38.08%, respectively, of the administered dose. para-Hydroxymethadone does not exhibit any opioid-like activity.

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Synthesis, characterization, and quantitation of para-hydroxymethadone, a metabolite of methadone in the rat

Bartos, F.; Bartos, D.; Olsen, G.D.; Anderson, B.; Daves, G.D. 1978: Stereospecific antibodies to methadone. II. Synthesis of d- and 1-methadone antigens Research Communications in Chemical Pathology and Pharmacology 20(1): 157-164
Albert, K.S.; Hallmark, M.R.; Sakmar, E.; Weidler, D.J.; Wagner, J.G. 1974: Plasma concentrations of diphenylhydantoin, its para-hydroxylated metabolite, and corresponding glucuronide in man Research Communications in Chemical Pathology and Pharmacology 9(3): 463-469
Masoud, A.N.; Bueding, E. 1983: Identification and quantitation of a metabolite of anethol dithiolthione in rat and mouse urine using high-performance liquid chromatography Journal of Chromatography 276(1): 111-119
Thompson, D.G.; Cowell, J.E.; Daniels, R.J.; Staznik, B.; MacDonald, L.M. 1989: Liquid chromatographic method for quantitation of glyphosate and metabolite residues in organic and mineral soils, stream sediments, and hardwood foliage Journal - Association of Official Analytical Chemists 72(2): 355-360
Ucer, U.; Bartsch, H.; Scheurich, P.; Berkovic, D.; Ertel, C.; Pfizenmaier, K. 1986: Quantitation and characterization of gamma-interferon receptors on human tumor cells Cancer Research 46(10): 5339-5343
Stearns, R.A.; Doss, G.A.; Miller, R.R.; Chiu, S.H. 1991: Synthesis and identification of a novel tetrazole metabolite of the angiotensin Ii receptor antagonist DuP 753 Drug Metabolism and Disposition: the Biological Fate of Chemicals 19(6): 1160-1162
Hignite, C.E.; Tschanz, C.; Huffman, D.H.; Azarnoff, D.L. 1978: Quantitation of N-demethylantipyrine in biological samples and isolation and characterization of its glucuronic acid conjugate Drug Metabolism and Disposition: the Biological Fate of Chemicals 6(3): 288-295
Grech-Bélanger, O.; Turgeon, J.; Lalande, M.; Bélanger, P.M. 1991: Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation Drug Metabolism and Disposition: the Biological Fate of Chemicals 19(2): 458-461
Smith, K.; Fennelly, J.A.; Neal, D.E.; Hall, R.R.; Harris, A.L. 1989: Characterization and quantitation of the epidermal growth factor receptor in invasive and superficial bladder tumors Cancer Research 49(21): 5810-5815
Tong, J.; Hoffman, R.; Siena, S.; Srour, E.F.; Bregni, M.; Gianni, A.M. 1994: Characterization and quantitation of primitive hematopoietic progenitor cells present in peripheral blood autografts Experimental Hematology 22(10): 1016-1024
Bundgaard, H. 1975: Identification and quantitation of a 3-benzylidenephthalide contaminant of phenindione tablets and its characterization as a potentially immunogenic substance Acta Pharmaceutica Suecica 12(4): 333-348
Morand, J.M.; Cussac, M.; Kaouadji, M.; Alary, J. 1987: Metabolic analysis of an aza-chalcol: 10184 CERM. Isolation of a urinary N-oxide metabolite from the rat and its synthesis Journal de Pharmacie de Belgique 42(4): 229-235
Golan, M.D.; Bücker, M.; Schmassmann, H.U.; Raphael, D.; Jung, R.; Bindel, U.; Brase, H.O.; Tegtmeyer, F.; Friedberg, T.; Lorenz, J.; Stasiecki, P.; Oesch, F. 1980: Characterization of dog hepatic drug-metabolizing enzymes and resultant effects on benzo[a]pyrene metabolite pattern and mutagenicity Drug Metabolism and Disposition: the Biological Fate of Chemicals 8(3): 121-126
Fennell, T.R.; Miller, J.A.; Miller, E.C. 1984: Characterization of the biliary and urinary glutathione and N-acetylcysteine metabolites of the hepatic carcinogen 1'-hydroxysafrole and its 1'-oxo metabolite in rats and mice Cancer Research 44(8): 3231-3240
Chenna, A.; Maruenda, H.; Singer, B. 1999: Synthesis of para-benzoquinone and 1,3-bis(2-chloroethyl)nitrosourea adducts and their incorporation into oligonucleotides Iarc Scientific Publications 150: 89-101
Miller, M.A.; Katzenellenbogen, B.S. 1983: Characterization and quantitation of antiestrogen binding sites in estrogen receptor-positive and -negative human breast cancer cell lines Cancer Research 43(7): 3094-3100
Koutsourea, A.I.; Fousteris, M.A.; Arsenou, E.S.; Papageorgiou, A.; Pairas, G.N.; Nikolaropoulos, S.S. 2008: Synthesis, in vivo antileukemic evaluation and comparative study of novel 5alpha-7-keto steroidal esters of chlorambucil and its active metabolite In Vivo 22(3): 345-352
Holman, W.L.; Kirklin, J.K.; Pacifico, A.D. 1992: Quantitation of mapping uncertainty in Wolff-Parkinson-White syndrome. Implications for anatomic characterization and surgical division of accessory atrioventricular connections Journal of Thoracic and Cardiovascular Surgery 104(4): 1045-1052
Benbow, E.W.; Roberts, I.S.; Cairns, A. 1996: Fatal methadone overdose. Better understanding of body's handling of methadone is needed Bmj 313(7070): 1479; Author Reply 1480
Aavitsland, P. 1998: Is methadone efficient? Methadone therapy versus evidence-based medicine Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 118(20): 3105