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Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation

Grech-Bélanger, O.; Turgeon, J.; Lalande, M.; Bélanger, P.M.

Drug Metabolism and Disposition the Biological Fate of Chemicals 19(2): 458-461

1991

ISSN/ISBN: 0090-9556
PMID: 1676654
Document Number: 380980
Meta-hydroxymexiletine [1-(3-hydroxy,2,6-dimethyl)phenoxy-2-amino-propane], a novel metabolite of the antiarrhythmic drug mexiletine, was isolated from urine of rats given mexiletine. The structure of the metabolite was elucidated by 1H-NMR and mass spectrometry and by IR spectrophotometry. The metabolite is produced in vitro by hepatic microsomes of various laboratory animals including rat, guinea-pig, hamster, rabbit, and mouse. In humans, meta-hydroxymexiletine accounts for approximately 2% of the administered dose of mexiletine.

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