Selective oxidation of thioxanthene derivatives
Tammilehto, S.; Pere, R.; Hämäläinen, M.L.
Acta Pharmaceutica Suecica 23(5): 289-294
1986
ISSN/ISBN: 0001-6675 PMID: 3565030 Document Number: 279891
The selective oxidation of thioxanthene derivatives with sodium metaperiodate and potassium permanganate was investigated. Sodium metaperiodate oxidizes the sulfide group of the thioxanthenes to a sulfoxide at room temperature, and to a sulfone at elevated temperature (60.degree. C). Potassium permanganate causes the whole side-chain of the thioxanthenes to split off, with formation of thioxanthen-9-one or thioxanthen-9-one-10,10-dioxide depending on the pH of the reaction milieu. The structures of the oxidation products were verified by physicochemical methods.