Changes in the anatomic structures and cellular composition of lymph nodes after prenatal exposure to oleandomycin
Dolgova, M.A.; Savitskaia, T.N.
Arkhiv Anatomii Gistologii i Embriologii 91(11): 53-60
1986
ISSN/ISBN: 0004-1947 PMID: 3813911 Document Number: 279244
Tracheobronchial and mesenteric lymph nodes have been investigated in 120 embryos, fetuses and newborn (5-, 14-, 30-day-old) rats by means of anatomical, histological and electron microscopical methods. Prenatal influence of oleandomycin phosphate on development of lymph nodes has been analysed. Effect of the drug on the mother--fetus system produces certain reactive changes in the anatomical structures responsible for the barrier-filtration and drainage functions of the lymph nodes. The immunocytopoietic function is inhibited, as demonstrates certain decrease of lymphatic line cells.