Essential trace metal excretion from rats with lead exposure and during chelation therapy
Victery, W.; Miller, C.R.; Goyer, R.A.
Journal of Laboratory and Clinical Medicine 107(2): 129-135
1986
ISSN/ISBN: 0022-2143 PMID: 3080537 Document Number: 278662
Urinary excretion of lead, zinc, calcium, magnesium, iron, copper, sodium and potassium was estimated in rats daily for 1 week after a 6-week exposure to Pb 10 000 mu g/ml drinking water. Beginning on the third day, half of the Pb-exposed and control rats were given intraperitoneally calcium disodium ethylenediaminetetraacetate (EDTA) daily for 3 days. Whole blood, plasma and kidney metal concentrations were estimated from samples obtained at the end of the experiment. Exposure to Pb increased urinary excretion, not only of Pb, but also of Ca, Mg, Zn, Cu and Fe. Excretion of Na and K was not affected. Chelation further increased excretion of Pb, Zn, Cu and Fe, but not Mg. The increase in Ca excretion during chelation treatment (beyond that resulting from Pb exposure itself) was accounted for by the Ca content of CaNa2-EDTA. EDTA treatment increased renal concentration of Zn, but lowered renal concentration of Pb, Cu and Fe.