Increased glutathione (GSH) content in livers of control and carbon tetrachloride poisoned rats treated with the anticalmodulin drug trifluoperazine (TFP)
De Ferreyra, E.C.; Bernacchi, A.S.; Castro, J.A.
Research Communications in Chemical Pathology and Pharmacology 53(3): 399-402
1986
ISSN/ISBN: 0034-5164 PMID: 3775106 Document Number: 276189
TFP administration to rats (50 mg/kg, ip) 6 hr after olive oil or CCl4 (1 mg/kg, ip as a 20% olive oil solution) significantly increases the GSH content in liver at 24 hr. The role of GSH increases in the late preventive effects against CCl4 hepatotoxicity is discussed. A link between the calcium/calmodulin (CaM) system and the GSH status in liver is postulated.