Evaluation of the action of a fat diet on the state of the liver poisoned by carbon tetrachloride
Sadykh-zade, K.S.; Volgarev, M.N.; Piatnitskiĭ, N.N.; Zhminchenko, V.M.; Mal'tsev, G.I.
Voprosy Pitaniia 27(4): 14-17
1981
ISSN/ISBN: 0042-8833 PMID: 7293097 Document Number: 182350
The effects of the diet containing different amounts of fat on the liver with CCl4 poisoning were studied in two series of experiments on 150 male Wistar rats. In the first series th priming was given in the presence of the laboratory diet for 1 1/2 months. In the second series, the 1 1/2-month priming was given in the presence of the diets tested. The control animals given no priming were kept on the laboratory diet in which the fat (sunflower oil) amount constituted 23% as regards the caloricity. The experimental animals were distributed into 2 groups kept on the diets containing 27 and 43% of fat as regards the caloricity (creamery butter and sunflower oil at a ratio of 2 : 1). All three diets were isocaloric, having the identical content of protein. Change in the fat amount was compensated for the respective change in the carbohydrate content. It was found that application of the diet with the increased content of milk and vegetable fat (43% as regards the caloricity) led to a marked improvement of the liver, while early application of the test diets in the presence of CCl4 brought about a significant decrease in the lethality of the experimental animals.