The use of microcrystalline cellulose dispersions for the production of dermatologic agents
George, J.; Hentzschel, S.; Hünerbein, B.; König, S.; Schäfer, W.
Die Pharmazie 41(8): 588-590
1986
ISSN/ISBN: 0031-7144 PMID: 3786383 Document Number: 273200
The employment oft microcrystalline cellulose of the Heweten-type (cellulose powder(AB-GDR) for the production of dermatological preparations as aqueous and aqueous-oily multicomponent systems can contribute to the opening of a further field of application of this auxiliary substance in pharmaceutical factories and pharmacies. By means of intensive shearing and mixing forces, e.g. a colloid mill, it is possible to produce dispersions with fluid media, which proved to be stable when they contained a solid content over 8 p.c. Such dispersions can improve the utilization properties of various preparations. By varying the solid content concentration one can produce dispersions of different properties. Microcrystalline cellulose powders meet the demands which characterize an auxiliary substance in general. Special attention has to be drawn on the problem of microbiological stability because of the necessarily high moisture content of the dispersion. Preparations manufactured by colloid wet grinding with microcrystalline cellulose are distinguished by a high physicochemical stability.