Topical hemostatic agents to reduce bleeding from cancellous bone. a comparison of microcrystalline collagen, thrombin, and thrombin-soaked gelatin foam
Cobden, R.H.; Thrasher, E.L.; Harris, W.H.
Journal of Bone and Joint Surgery. American Volume 58(1): 70-73
1976
ISSN/ISBN: 0021-9355 PMID: 1249114 Document Number: 96432
In fifty-three dogs microcrystalline collagen, thrombin-soaked gelatin foam, and thrombin powder were evaluated as hemostatic agents when applied to bleeding cancellous surfaces after osteotomy of the greater trochanter using two quantitative models: one, a single osteotomy; the other, a double osteotomy. All three agents significantly reduced bleeding compared with the controls, the microcrystalline collagen being most effective. At three months there was no evidence that microcrystalline collagen and thrombin-gelatin interfered with bone healing after the greater trochanter was reattached with two wires.