Effect of verapamil on the molecular characteristics of myocardial actomyosin in experimental ischemia
Kaĭfadzhian, M.A.; Dzhanpoladian, E.G.; Zaminian, T.S.; Samvelian, V.M.; Oganesian, S.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(1): 46-48
1986
ISSN/ISBN: 0365-9615 PMID: 2417642 Document Number: 271043
Verapamil was shown to be able to recover a significantly depressed actomyosin ATPase activity of the unaffected left ventricular area in experimental myocardial ischemia. The drug also increased Ca-sensitivity of the ATPase reaction, with the amount of actomyosin components (Tn-1, LCM-1, LCM-2, Tn-C) almost reaching the control level. The possibility of direct interaction of verapamil with Ca-binding sites on actomyosin macromolecule is suggested. Its influence on metabolism and gene expression is not excluded.