Effect of intracerebroventricularly injected copper on rectal temperature of rabbits
Saxena, P.; Varshney, V.; Chandra, O.; Saxena, P.N.
Indian Journal of Medical Research 84: 650-656
1986
ISSN/ISBN: 0019-5340 PMID: 3106202 Document Number: 270857
Intracerebroventricular injection of 0.01 to 10 .mu.g of copper evoked a dose-dependent hyperthermia in rabbits. Injection of 100 .mu.g copper caused motor excitement followed by depression and fall in rectal temperature. The rise in temperature was due to Cu2+ and not to the associated anion in the salt. It was centrally mediated as the same doses failed to affect the temperature when injected intravenously. The hyperthermia was mediated mainly through adrenergic mechanism as phenoxybenzamine antagonized and 6-OHDA abolished it. Interaction with PG synthesis inhibitors, which evoked hypothermia of varying degree, appeared to be due to physiological antagonism.