Effects of synthetic new drug SC1001-sodium on respiratory frequency, heart rate, rectal temperature and electrocorticogram in rabbits
Chen, Q.X.; Chai, H.X.; Xie, Y.G.; Xu, J.G.
Hua Xi Yi Ke da Xue Xue Bao 20(1): 28-30
1989
ISSN/ISBN: 0257-7712 PMID: 2793137 Document Number: 335876
Seventeen normal male rabbits weighing 1.7-2.8 kg were randomly divided into 2 groups. The experimental group (ten rabbits) was injected with SC1001Na (200 mg/kg, i.p.). The control group (seven rabbits) was injected with normal saline of the same volume. Continuous observations for 6 hours were made after injection, with reference to respiratory frequency (RF), heart rate (HR), rectal temperature (RT) and ECoG of these rabbits. The results of experiments indicate that SC1001Na has a slight inhibitory effect on RF and RT, an obvious inhibitory effect on the activity of central nervous system, and an accelerating effect on HR in rabbits.