Cell wall antigenic determinants in ribosomal preparations of Streptococcus group a
Shikhman, A.R.; Nikolaeva, L.V.; Kondrakova, O.A.; Dzantiev, B.B.; Blinnikova, E.I.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 15-19
1985
ISSN/ISBN: 0372-9311 PMID: 2409717 Document Number: 267012
As revealed by double immunodiffusion and the competitive immunoenzyme assay, the immunization of animals with ribosomes isolated from group A streptococci leads to the formation of antibodies to M-protein and does not lead to the formation of antibodies to A-polysaccharide and lipoteichoic acid, which is seemingly caused by the presence of M-protein in ribosomes. Antiribosomal serum has permitted the detection of more antigenic determinants in M-protein than commercial antiserum to homologous M-protein. The immunoenzyme assay for the quantitative determination of ribosomes has been developed.