Plasma apolipoprotein pattern in fish-eye disease examined by high-resolution two-dimensional electrophoresis
Marshall, T.; Williams, K.M.; Holmquist, L.; Carlson, L.A.; Vesterberg, O.
Clinical Chemistry 31(12): 2032-2035
1985
ISSN/ISBN: 0009-9147 PMID: 3933853 Document Number: 266381
We compared the plasma protein patterns of the two living patients suffering from fish-eye disease with those of appropriate controls, using high-resolution two-dimensional electrophoresis. Quantitative abnormalities were detected in plasma polypeptides corresponding to the isoforms of apolipoproteins A-I and A-II. The disease was characterized by normal concentrations of proapo A-I but dramatically subnormal concentrations of the other apo A-I isoforms and apo A-II. No significant difference was detected in the concentrations of other plasma proteins. These findings are discussed in relation to other apolipoprotein disorders.