Parallel induction of IgE-mediated Ascaris antigen airway responses and increased carbachol airway reactivity in rhesus monkeys by infection with Ascaris suum
Patterson, R.; Harris, K.E.
Journal of Laboratory and Clinical Medicine 106(3): 293-297
1985
ISSN/ISBN: 0022-2143 PMID: 4031630 Document Number: 258311
The duration of IgE-mediated skin reactivity and airway responses to Ascaris antigen in 4 rhesus monkeys infected with A. suum from 15 weeks to 2.8 years is reported. A 2nd group of 4 rhesus monkeys was infected with A. suum ova after determination of the threshold of airway reactivity to carbachol. Evaluation of these animals confirmed the initial results of the first group of animals studied in relation to induction of skin and airway reactivity to Ascaris antigen. All animals developed increased airway reactivity demonstrated by increased reactivity to lower concentrations of carbachol. This demonstrates induced IgE-mediated antigen airway responsiveness accompanied by induction of increased airway reactivity in a primate model. This increased activity does not appear to be related to the induction of IgE antibody.