The effect of diet on the metabolism of long acting theophylline
Tinkelman, D.G.; Edelman, L.; Decouto, J.; Maloch, L.D.; Spangler, D.L.
Annals of Allergy 54(4): 280-283
1985
ISSN/ISBN: 0003-4738 PMID: 3985423 Document Number: 255923
Recently some concern has been expressed of the effect of diet on the metabolism of theophylline. This brief trial in normal healthy adults observed the effect of fasting, high fat, low fat, and liquid fat/low carbohydrate diet on the metabolism of a sustained-release theophylline preparation (Theo-Dur). On analysis of the mean theophylline level values, there were no significant differences in the theophylline levels between the diets. However, in certain individuals there were differences in the theophylline absorption rates between diets. No consistent pattern was seen.