Development of cardiac adenylate cyclase hypersensitivity to isoproterenol in the chronic action of propranolol on rats
Tkachuk, V.A.; Cherkasova, T.D.
Problemy Endokrinologii 31(2): 49-52
1985
ISSN/ISBN: 0375-9660 PMID: 2986093 Document Number: 255805
The chronic treatment of rats with the beta-adrenergic antagonist propranolol causes a double increase in the amount of beta-adrenergic receptors in the cardiac membranes. The purpose of the paper is to investigate the effect of propranolol on the activity and regulatory properties of rat heart adenylate cyclase. Propranolol injections to rats for 3 weeks (10-20 mg/l kg bw) did not influence the enzyme basal activity but caused a rise of a degree of myocardial adenylate cyclase activation by isoproterenol and glucagon.