Adenylate cyclase system of the striatum in rats: regulatory properties and effect of gangliosides
Plesneva, S.A.; Nalivaeva, N.N.; Zhuravin, I.A.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 83(1-2): 90-95
1997
ISSN/ISBN: 0869-8139 PMID: 13676990 Document Number: 480256
Gpp[NH]p, forskolin, and NaF were found to activate the activity of adenylate cyclase in vitro in the membrane fraction of the striatum. Gangliosides decreased the level of basal activity of the striatal adenylate cyclase. Gangliosides were shown to modulate the activity of the enzyme through changes in its catalytic properties.
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