Metabolite inhibition of nitroglycerin metabolism in sheep tissue homogenates
Cossum, P.A.; Roberts, M.S.
Journal of Pharmacy and Pharmacology 37(11): 807-809
1985
ISSN/ISBN: 0022-3573 PMID: 2867162 Document Number: 255122
The metabolism of nitroglycerin in sheep tissue homogenates has been examined using tritiated nitroglycerin and a HPLC separation procedure. Nitroglycerin was metabolized by liver, lung, muscle, arterial and venous tissue to its dinitrometabolites and subsequently to mononitroglycerin. Addition of the dinitrometabolites substantially inhibited the degradation of nitroglycerin in all tissue homogenates.
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