The effect on oxidative metabolism in brain, liver and heart muscle homogenates of peptide derivatives and calf blood dialysates
Windisch, M.; Piswanger, A.
Arzneimittel-Forschung 35(1): 87-89
1985
ISSN/ISBN: 0004-4172 PMID: 4039157 Document Number: 247436
Three peptide preparations, derived from different proteins, and one protein free extract, produced by dialysis of calf blood, were tested. Typical effects of the individual preparations on oxidative metabolism could be shown. A comparable high stimulation of oxygen consumption of brain homogenates by 117 to 165% was measured after application of the peptide derivatives. One of them, the peptide enriched derivative, caused a high and not organ specific stimulation, increasing the oxygen consumption of brain, liver and heart muscle by 165, 203 and 202%, respectively, thus exceeding the effects of the other tested preparations. Extracts of calf blood, which showed maximal stimulation in liver homogenate (98%), led to rather small effects in brain homogenate (51%) compared with those induced by the peptide derivatives.