Interaction of complement solubilized complexes with mouse peritoneal macrophages and their clearance and tissue uptake
Takahashi, N.; Fujita, T.; Takata, Y.; Tamura, N.
Clinical and Experimental Immunology 61(1): 176-182
1985
ISSN/ISBN: 0009-9104 PMID: 3899427 Document Number: 252688
To clarify the biological activity of complement solubilized immune complexes, their interaction with mouse peritoneal macrophages (MPM) was studied. The solubilized complexes lost their binding affinity for complement component C3b receptor and Fc receptor but still bound to MPM mainly via the C3bi receptor (CR3). When solubilized immune complexes were injected into mice, they were more rapidly removed from the circulation than antigen excess soluble complex and taken up by the liver Kupffer cells. Therefore, the solubilized complexes could be catabolized by the RES, mainly in the liver. CR3 probably plays an important role in this process.