The effect of the beta-blocker nadolol on the second messenger, serum cyclic adenosine monophosphate, and on blood pressure and heart rate
Weth, G.; Schneider, J.; Rodatz, H.; Haubitz, I.
Arzneimittel-Forschung 35(11): 1711-1713
1985
ISSN/ISBN: 0004-4172 PMID: 2868733 Document Number: 252096
In this investigation it could be shown that the intracellular alterations of cAMP (cyclic adenosine monophosphate) caused by the beta-receptor blocker (2R,3S)-5-(3-tert-butylamino-2-hydroxypropoxy)-1,2,3,4- -tetrahydro-2,3-naphtalenediol (nadolol, Solgol mite) can also be proved in plasma. 15 hypertensive patients were given 60 mg nadolol; before and after certain intervals plasma cAMP, blood pressure, heart rate and pulmonary function were measured. After a single dose of nadolol within 8 h a prompt, significant decrease of the plasma cAMP concentration from 21.3 pmol/ml to 8.1 pmol/ml could be seen. 8 h later the cAMP concentration increased slowly and after 32 h achieved an average value of 13.1 pmol/ml. Heart rate and systolic blood pressure of the patients showed nearly identical behavior for more than 32 h. Both parameters fell significantly, increased slowly after 8 h and were still on a lower level after 32 h. There was no influence on diastolic blood pressure value and pulmonary function. The results confirm--in accordance with other investigators--the long therapeutical effect of the beta-receptor blocker nadolol; besides they prove that the model used here is a suitable biochemical equivalent in comparison to the pharmacological effect of a beta-receptor blocker.