Role of mitotic counts in the grading and prognosis of the breast cancer
Patel, C.; Sidhu, K.P.; Shah, M.J.; Patel, S.M.
Indian Journal of Pathology and Microbiology 45(3): 247-254
2002
ISSN/ISBN: 0377-4929 PMID: 12785160 Document Number: 250717
100 Cases of invasive breast cancer were studied for Tumor type, Tumor site, Nodal Status, Mitotic counts, Nuclear pleomorphism, Tubule formation and Nottingham modification of Bloom Richardson Grading. The follow up of the 82 patients treated with surgery and adjuvant treatment was available. Mitotic activity index (MAI) counted with strict criteria of elston CW, emerged as one of the most significant prognostic parameter followed by overall grade in predicting Tumor free survival (TFS) for the patients. Mitotic count also correlated well with overall Grade and lymph node status in predicting the TFS. This parameter is very useful where advanced studies like flowcytometry and immunohistochemical studies of the cell proliferation marker are not available.