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Hormone synthesis by primary breast carcinomas and prognosis in human breast cancer

Di Martino, L.; Tarquini, A.; Mitchell, I.; Deshpande, N.

Tumori 66(2): 197-203

1980

ISSN/ISBN: 0300-8916
PMID: 6449771
Document Number: 164522
The ability of human breast carcinomas to convert pregnenolone to progesterone and dehydroepiandrosterone to .DELTA.4-androstene-3,17=dione (.DELTA.4) was investigated as a potential aid for prognosis, and the following observations were recorded. 1. Neither the amounts of progesterone or .DELTA.4 synthesized nor .DELTA.4/progesterone ratios correlated with tumor size or lymph node invlvement. 2. .DELTA.4 synthesis was lower in carcinomas from patients who had recurrences within 2 yr of mastectomy than in carcinomas from those who remained free of metastases. 3. Life table analysis of the results indicated that these parameters appeared unlikely to be useful aids for prognosis.

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