Breast cancer prognosis. II. Prognostic factors in patients with node-positive (N1-3) breast cancer
Rudan, I.; Skorić, T.; Rudan, N.
Acta Medica Croatica Casopis Hravatske Akademije Medicinskih Znanosti 48(4-5): 165-170
1994
ISSN/ISBN: 1330-0164 PMID: 7534518 Document Number: 431323
Predictors of breast cancer survival were investigated among 282 node-positive (N1-3) breast cancer patients treated at the Department of Surgery of the University Hospital for Tumors in Zagreb between 1969-1988. Selected prognostic factors included patient age, delay in treatment, tumor size, type of lymph-node affection, pathohistological grade of malignancy, estrogen receptor status, progesterone receptor status, tumor site, and type of surgical treatment. Among these predictors, only tumor size (p lt 0.001), type of lymph-node affection (p lt 0.001), malignancy grade (p lt 0.001), and progesterone receptor status (p lt 0.001) revealed a significant impact on a 5-year overall survival rates (T1-100%, T2-64.5%, T3-54.5% and T4-23.7%; N3-60.2%, N2-20.8%, N3-30.3%; grade I-85. 5%, II-59.4%, III-30.5%; PgR+ 63.8%, PgR-26.4%). The authors conclude that among nine selected characteristics, only tumor size, type of lymph-node affection, pathohistological malignancy grade, and progesterone receptor status can be helpful predictors in the determination of the probability of 5-year overall survival among node-positive breast cancer patients.