Identification of transforming growth factor alpha in human primary breast carcinomas
Macias, A.; Perez, R.; Hägerström, T.; Skoog, L.
Anticancer Research 7(6): 1271-1275
1987
ISSN/ISBN: 0250-7005 PMID: 3502066 Document Number: 291269
Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus indentified as Tumor Growth Factor (TGF) alpha, could be identified in 25% of the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.
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