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An assay for screening drugs against animal-infective bloodstream forms of Trypanosoma brucei brucei in vitro

Borowy, N.K.; Hirumi, H.; Waithaka, H.K.; Mkoji, G.

Drugs under Experimental and Clinical Research 11(3): 155-161

1985

ISSN/ISBN: 0378-6501
PMID: 3836123
Document Number: 248707
A rapid and simple assay for in vitro drug screening has been established using the mammalian feeder layer cell system for continuous cultivation of infective bloodstream forms of Trypanosoma brucei brucei. A total of 21 trypanocides have been tested. Differences in sensitivity to standard trypanocides were detected among drug-susceptible isolates and strains of T. b. brucei. This assay may thus be of potential use for rapid detection of new drug-resistant isolates of T. b. brucei.

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