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Clinical evaluation of a new parenteral penicillin, aspoxicillin, in children

Kim, B.; Meguro, H.; Mashiko, J.; Yonezawa, H.; Kawaoi, T.; Tajima, T.; Fujii, R.

Japanese Journal of Antibiotics 38(7): 1835-1845

1985

ISSN/ISBN: 0368-2781
PMID: 4068222
Document Number: 247485
Aspoxicillin (ASPC) was evaluated for its efficacy and safety in 30 infants and children with acute bacterial infections. The disease categories included acute respiratory tract (22), soft tissue (3), urinary tract (3) infections, sepsis with pyothorax (1) and purulent meningitis (1). ASPC was effective in all but 1 case of pneumonia due to .beta.-lactmase-positive Haemophilus influenzae (effective rat; 96.7%). Adverse reactions and abnormalities of the laboratory tests were not associated with the ASPC therapy in any of the cases. The serum half-life of ASPC after an intravenous bolus injection was 0.883 .+-. 0.194 hour and excretion into urine was rapid. From the present results, ASPC is a safe and effective antibiotic when used in patients with susceptible bacterial infections.

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Habrda, J.; Malíková, M. 1976: Persistance of penicillin residues in the calf organism after parenteral therapeutical administration of the preparation penicillin G, procaine inj ad usum vet Veterinarni Medicina 21(3): 161-166
Siripongpreeda, N.; Hattasingh, W.; Amornvipas, P.; Eampokalap, B.; Sakoolgnam, S.; Pancharoen, C.; Thisyakorn, U. 2010: Frequency and clinical course of invasive pneumococcal disease caused by penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae in Thai children Journal of the Medical Association of Thailand 93(Suppl 5): S1-S5
Stimmel, H.M.; Orchen, J.J.; Skaff, D.M.; Brown, A.T.; Spedding, R.H. 1981: Penicillin-resistant alpha-hemolytic streptococci in children with heart disease who taken penicillin daily Asdc Journal of Dentistry for Children 48(1): 29-32
Flatberg, P.; Wessman, J. 1971: Parenteral administration of penicillin. Adding the drug to intravenous infusions Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 91(34): 2498-2502
Mordovtsev, V.N.; Bednova, V.N.; Nazarova, A.J. 1987: Treatment of secondary recurrent and early latent syphilis with penicillin and ethamide: clinical and experimental evaluation Dermatologische Monatschrift 173(9): 532-534
Boles, J.M. 1987: Clinical, biological and immunological surveillance of parenteral feeding. An evaluation Revue de l'Infirmiere 37(11): 31-33
Ames, M.M.; Richardson, R.L.; Kovach, J.S.; Moertel, C.G.; O'Connell, M.J. 1990: Phase i and clinical pharmacological evaluation of a parenteral hexamethylmelamine formulation Cancer Research 50(1): 206-210
Mann, J.M.; Coleman, D.L.; Boylan, J.C. 1971: Stability of parenteral solutions of sodium cephalothin, cephaloridine, potassium penicillin G (buffered) and vancomycin hydrochloride American Journal of Hospital Pharmacy 28(10): 760-763
Widhalm, K. 1983: Current status of parenteral feeding with fat emulsions. Clinical experience in children Infusionstherapie und Klinische Ernahrung 10(4): 225-228
Morales Lepe, C.; Alpizar Espejel, S.; Cordero Jaime, M.A. 1978: Clinical analysis and evaluation of various hematologic and metabolic constants with the use of monthly microdoses of parenteral contraceptives Ginecologia y Obstetricia de Mexico 43(255): 47-52
Domański, A. 1985: Clinical evaluation of the utilization of the umbilical vein in the diagnosis of portal hypertension and parenteral therapy Annales Academiae Medicae Stetinensis 31: 67-83
Arushanian, E.B.; Avakian, R.M.; Kozlov, V.K.; Pergaev, A.P. 1979: Role of the catecholaminergic mechanisms and of the caudate nucleus in the development of generalized convulsions caused by the parenteral administration of penicillin Biulleten' Eksperimental'noi Biologii i Meditsiny 88(7): 12-15
Allen, E.D.; Byrd, S.E.; Darling, C.F.; Tomita, T.; Wilczynski, M.A. 1993: The clinical and radiological evaluation of primary brain tumors in children, Part I: Clinical evaluation Journal of the National Medical Association 85(6): 445-451
Langley, J.M.; Halperin, S.A.; Bortolussi, R. 2002: History of penicillin allergy and referral for skin testing: evaluation of a pediatric penicillin allergy testing program Clinical and Investigative Medicine 25(5): 181-184
Shu, S.-G.; Chen, Y.-D.; Chi, C.-S. 2002: Clinical evaluation of short children referred by school screening: an analysis of 655 children Acta Paediatrica Taiwanica 43(6): 340-344
Iwai, S.; Shishido, H. 1994: Revaluation of current antimicrobials. Series 23: aspoxicillin Japanese Journal of Antibiotics 47(12): 1621-1628
Nakai, K.; Tokushima, T.; Hirota, Y.; Nagamatsu, M.; Takeda, K.; Mizobe, M.; Takai, C. 1993: Pharmacokinetic study on aspoxicillin transfer into pulmonary and tracheal tissues Japanese Journal of Antibiotics 46(5): 367-373
Yamaguchi, T.; Ishii, N.; Tani, K.; Matsushita, T.; Matsumoto, K. 1989: Therapeutic effect of aspoxicillin on experimental pneumonia with Klebsiella pneumoniae in mice Drugs under Experimental and Clinical Research 15(6-7): 291-296
Arakawa, S.; Matsui, T.; Maeda, H.; Sako, M.; Sugino, M.; Ka, S.; Nakasuji, T.; Fujii, A.; Kamidono, S.; Maezawa, I. 1988: Pharmacokinetics and urinary excretion of aspoxicillin after consecutive administration at a dose of 4 grams Japanese Journal of Antibiotics 41(1): 37-47
Von Sydow, C.; Axelsson, A.; Jensen, C. 1984: Treatment of acute maxillary sinusitis. Erythromycin base and phenoxymethyl-penicillin (penicillin V) Rhinology 22(4): 247-254