Correcting an immune-response deficiency by creating E alpha gene transgenic mice
Le Meur, M.; Gerlinger, P.; Benoist, C.; Mathis, D.
Nature 316(6023): 38-42
1985
ISSN/ISBN: 0028-0836 PMID: 3925351 Document Number: 243711
We have introduced a cloned Ek alpha gene into embryos of mice incapable of expressing their endogenous E alpha genes. The transcription of Ek alpha was accurate and tissue-specific in the resulting transgenic lines and, in macrophages, Ek alpha transcription could be induced by gamma-interferon. The injected gene conferred on the genetically deficient host strain the ability to mount an immune response to a synthetic polymer.
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