Top Abstract Purchase Related
Home
>
Node
>
Subnode

The effect of the X-linked immune deficiency gene (xid) upon the y chromosome-related disease of BXSB mice

Smith, H.R.; Chused, T.M.; Steinberg, A.D.

Journal of Immunology 131(3): 1257-1262

1983

ISSN/ISBN: 0022-1767
PMID: 6886419
Document Number: 199892
BXSB mice develop a lupus-like disease characterized by B cell hyperplasia, hypergammaglobulinemia, autoantibodies, nephritis and coronary artery disease. To determine the subset of B cells responsible for disease in these mice, we bred a congenic BXSB.xid strain (greater than 99.2% inbred) with the xid gene that deletes a subset of splenic B cells. Because BXSB disease is associated with the Y chromosome, BXSB males and the autoimmune cross (NZB X BXSB)F1 males were studied. BXSB.xid males had profoundly reduced lymphoid hyperplasia, hypergammaglobulinemia, autoantibodies, renal disease, cardiac disease, and markedly prolonged survival. (NZB.xid/+ X BXSB)F1 males also demonstrated a marked protection associated with the xid gene. These studies suggest that the autoimmune disease of BXSB males is dependent upon the B cell subset deleted by xid.

Document emailed within 1 workday
Secure & encrypted payments

Golding, B.; Golding, H.; Foiles, P.G.; Morton, J.I. 1983: CBA/N X-linked defect delays expression of the Y-linked accelerated autoimmune disease in BXSB mice Journal of Immunology 130(3): 1043-1046
Miyawaki, S.; Nakamura, Y.; Takeshita, T.; Yoshida, H.; Shibata, Y.; Mitsuoka, S. 1988: Marked acceleration of the autoimmune disease in MRL-lpr/lpr mice by the influence of the Yaa gene from BXSB mice Laboratory Animal Science 38(3): 266-272
Kofler, R.; McConahey, P.J.; Duchosal, M.A.; Balderas, R.S.; Theofilopoulos, A.N.; Dixon, F.J. 1991: An autosomal recessive gene that delays expression of lupus in BXSB mice Journal of Immunology 146(4): 1375-1379
Creighton, W.D.; Zinkernagel, R.M.; Dixon, F.J. 1979: T cell-mediated immune responses of lupus-prone BXSB mice and other murine strains Clinical and Experimental Immunology 37(2): 181-189
Le Meur, M.; Gerlinger, P.; Benoist, C.; Mathis, D. 1985: Correcting an immune-response deficiency by creating E alpha gene transgenic mice Nature 316(6023): 38-42
Wu, Y.; Wang, Lü-ya.; Zhang, H-xin.; Chen, D.; Wang, W.; Xiao, L.; Fang, W.; Wang, F.; Shang, J-feng. 2007: Effects of the total flavone of radix puerariae on apoptotic cell and apoptotic related-gene in atherosclerotic plaques of apoE gene deficiency mice Zhonghua Xin Xue Guan Bing Za Zhi 35(6): 567-570
Hersh, E.M.; Mansell, P.W.; Reuben, J.M.; Rios, A.; Newell, G.R. 1984: Immunological characterizations of patients with acquired immune deficiency syndrome, acquired immune deficiency syndrome-related symptom complex, and a related life-style Cancer Research 44(12 Part 1): 5894-5901
Sustrová, M.; Saríková, V. 1997: Down's syndrome--effect of increased gene expression in chromosome 21 on the function of the immune and nervous system Bratislavske Lekarske Listy 98(4): 221-228
Izui, S.; Hara, I.; Hang, L.M.; Elder, J.H.; McConahey, P.J.; Dixon, F.J. 1984: Association of elevated serum glycoprotein gp70 with increased gp70 immune complex formation and accelerated lupus nephritis in autoimmune male BXSB mice Clinical and Experimental Immunology 56(2): 272-280
Okuda, K.; Christadoss, P.R.; Twining, S.; Atassi, M.Z.; David, C.S. 1978: Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control Journal of Immunology 121(3): 866-868
Wolff, K. 1986: Neopterin in homosexuals acquired immune deficiency syndrome related complex and acquired immune deficiency syndrome patients a parameter for the activity of the lymphadenopathy associated virus human t cell leukemia virus iii infection Acta Medica Austriacaec. Issue: 41-42
Wolff, K. 1986: Neopterin in homosexuals acquired immune deficiency syndrome related complex and acquired immune deficiency syndrome patients a parameter for the activity of the lymphadenopathy associated virus human t cell leukemia virus iii infection Acta Medica Austriacaec. Issue: 41-42
Li, M.-l.; Fang, H.-j.; Fan, X.-l.; Zhang, J.; Yan, J.; Sun, A.-h. 2013: Distribution of Salmonella paratyphi a outer membrane protein X gene and immune-protective effect related to its recombinant expressed products Zhonghua Liu Xing Bing Xue Za Zhi 34(12): 1219-1222
Harada, S.; Sakamoto, K.; Seeley, J.K.; Lindsten, T.; Bechtold, T.; Yetz, J.; Rogers, G.; Pearson, G.; Purtilo, D.T. 1982: Immune deficiency in the X-linked lymphoproliferative syndrome. I. Epstein-Barr virus-specific defects Journal of Immunology 129(6): 2532-2535
Collins, N.; McManus, R.; Wooster, R.; Mangion, J.; Seal, S.; Lakhani, S.R.; Ormiston, W.; Daly, P.A.; Ford, D.; Easton, D.F. 1995: Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13 Oncogene 10(8): 1673-1675
Li, H.; Gao, R.; Wu, M.; Fu, M.; Wu, K.; Yang, Y.; Wang, X.; Wang, Z.; Liu, S. 2004: Effects of entrapment of murine interleukin-2 gene with chitosan nanoparticles on expression of mIL-2 gene and on regulation of immune response in mice Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21(6): 947-952
Zalman, M.A.; Meruelo, D. 1987: Phosphoproteins recognized by an H-2-linked immune response gene and their association with cell proliferation Cancer Research 47(1): 193-200
Král, V.; Jílek, D.; Pajerek, J.; Stasný, J.; Kofer, J.; Vávra, M.; Richter, J. 1990: X chromosome-linked lymphoproliferative syndrome (Duncan's disease) Casopis Lekaru Ceskych 129(8): 247-251
Kenny, J.J.; Stall, A.M.; Sieckmann, D.G.; Lamers, M.C.; Finkelman, F.D.; Finch, L.; Longo, D.L. 1991: Receptor-mediated elimination of phosphocholine-specific B cells in x-linked immune-deficient mice Journal of Immunology 146(8): 2568-2577
Ohsugi, Y.; Gershwin, M.E.; Ahmed, A.; Skelly, R.R.; Milich, D.R. 1982: Studies of congenitally immunologic mutant New Zealand mice. VI. Spontaneous and induced autoantibodies to red cells and DNA occur in New Zealand X-linked immunodeficient (Xid) mice without phenotypic alternations of the Xid gene or generalized polyclonal B cell activation Journal of Immunology 128(5): 2220-2227