Effect of increased levels of free fatty acids on the size of the ischaemic area
Pérez-Medina, T.; Udvary, E.; Szekeres, L.
Cor et Vasa 27(1): 87-91
1985
ISSN/ISBN: 0010-8650 PMID: 3995996 Document Number: 243695
Mongrel dogs, anesthetized with sodium pentobarbital were artificially ventilated and prepared to produce a 3-min occlusion of the left descending coronary artery. High serum levels of free fatty acids (FFA) were obtained by infusion of Lipofundin [1 and 3 ml/min]. A significant increase in the size of the ischemic area was found following a 3 ml/min infusion rate of Lipofundin. Ventricular extrasystoles and ventricular fibrillation appeared in 2 out of 7 and 1 of 7 dogs, respectively. High levels of FFA early after coronary occlusion increases the size of the ischemic area and secondarily produces ventricular arrhythmias.